Module 4: Severe Hypercholesterolemia & FH
Management of severe hypercholesterolemia and familial hypercholesterolemia.
LDL Cholesterol Severity Assessment
Enter the untreated LDL Cholesterol level to determine the severe hypercholesterolemia pathway.
Dutch Lipid Clinic Network Score
Score: 0Interactive scoring tool for clinical assessment of familial hypercholesterolemia likelihood. Select the highest-scoring criterion within each category.
1. Family History
0 pts2. Personal Clinical History
0 pts3. Physical Examination
0 pts4. LDL Cholesterol Level (Untreated)
0 ptsEnter an untreated LDL Cholesterol value in Section 1 above to auto-score this category.
5. DNA Analysis
0 ptsTotal Score
Classification
Unlikely Familial HypercholesterolemiaScore < 3: Familial hypercholesterolemia is unlikely based on clinical criteria. Continue standard lipid management.
0
Family History
0
Personal History
0
Physical Exam
0
LDL Cholesterol
0
DNA
Lipoprotein(a) Assessment
Class IIa / Level B-NRLipoprotein(a) is a genetically determined, independent risk factor for atherosclerotic cardiovascular disease. Measurement is recommended at least once in a lifetime.
Why measure lipoprotein(a) in this patient?
- Lipoprotein(a) measurement is recommended at least once in all adults for atherosclerotic cardiovascular disease risk assessment (Class 1, Level B-NR). This is a universal recommendation — no special indication is required.
- Familial hypercholesterolemia or severe hypercholesterolemia (LDL cholesterol >= 190 mg/dL) is present. Elevated Lipoprotein(a) may contribute to the LDL cholesterol elevation and further increases atherosclerotic cardiovascular disease risk.
Enter value in nmol/L. To convert from mg/dL, multiply by ~2.5.
IMPORTANT: This software is clinical decision support (CDS) intended for use by licensed healthcare professionals under Section 520(o)(1)(E) of the Federal Food, Drug, and Cosmetic Act. It is not intended as a medical device. All recommendations are derived from the 2026 ACC/AHA Guideline on the Management of Dyslipidemia and must be independently verified by the treating clinician before any clinical action. AI-generated content (including extracted data and clinical notes) is produced by large language models and may contain errors, omissions, or hallucinations — clinician review is mandatory. Patient data entered into the calculator is processed entirely in the browser; AI features process data server-side under a signed HIPAA Business Associate Agreement with no data retention. AI-HEART Lab, its affiliates, and contributors assume no liability for clinical decisions made using this tool. By using this tool, you acknowledge these limitations and accept full responsibility for clinical decisions.