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Module 3: Severity Assessment

Stratify PE severity using PESI, simplified PESI (sPESI), and Bova score for hemodynamic deterioration risk.

Pre-Test Prob.D-DimerSeverity (PESI)Category (A–E)Hestia CriteriaAnticoagulationDurationAdvanced RxSpecial Populations

Vitals & Demographics

yrs
bpm
mmHg
/min
°C
%

PESI

60
points

Source: 2026 AHA/ACC PE Guideline, Table 6. Starts at age in years.

HR ≥110 (+20), SBP <100 (+30), RR ≥30 (+20), Temp <36°C (+20), SpO2 <90% (+20) are derived from vitals above.

Class I — Very Low Risk
30-day mortality: 0–1.6%
1
Class I: ≤65 | Class II: 66–85 | Class III: 86–105 | Class IV: 106–125 | Class V: >125

sPESI

0
points

Source: 2026 AHA/ACC PE Guideline, Table 6 — Simplified PESI (1 point each criterion)

Low Risk
Estimated 30-day mortality: ~1.0% (30-day)

Bova Score

0
points

Source: 2026 AHA/ACC PE Guideline, Table 6 — For intermediate-risk PE risk stratification

Bova Stage I
Score 0–2 — 30-day complications ~4.4%

IMPORTANT: This software is clinical decision support (CDS) intended for use by licensed healthcare professionals under Section 520(o)(1)(E) of the Federal Food, Drug, and Cosmetic Act. It is not intended as a medical device. All recommendations are derived from the 2026 AHA/ACC/ACCP/ACEP/CHEST/SCAI/SHM/SIR/SVM/SVN Guideline for the Evaluation and Management of Acute Pulmonary Embolism (Circulation 2026;153:e977-e1051) and must be independently verified by the treating clinician before any clinical action. AI-generated content (including extracted data and clinical notes) is produced by large language models and may contain errors, omissions, or hallucinations — clinician review is mandatory. Patient data entered into the calculator is processed entirely in the browser; AI features process data server-side under a signed HIPAA Business Associate Agreement with no data retention. AI-HEART Lab, its affiliates, and contributors assume no liability for clinical decisions made using this tool. By using this tool, you acknowledge these limitations and accept full responsibility for clinical decisions.